Advantages of LDN
Because LDN is yet an experiential treatment for chronic pain, a significant promise is required to justify promoting its use. LDN offers several advantages that might make it an engaging treatment choice, some of which are mentioned below.
As a generic medicine, naltrexone HCl is usually low-priced. While cost can differ considerably by area and pharmacy, the average cost of Low Dose Naltrexone appears to US$35/month. This price includes compounding and no insurance coverage. The cost is much cheaper than what people usually pay for modern on-patent medicines, which can charge over US$100 every month.
Fewer side effects
One of the most interesting aspects of LDN is the reduced reported frequency of disadvantageous side effects. We haven’t noticed occurrences of ulcers, drug interaction with warfarin and different common medications, renal insufficiency, developed chances of heart attack or risk of clotting, or additional problems that can be observed with the use of nonsteroidal anti-inflammatory drugs. Researchers have seen no cases of critical adverse events in their research, and nor have any been reported from different laboratories. There have been witnessed no withdrawal symptoms at the end of LDN treatment, and withdrawal is not an identified impact of treatment discontinuance. However, the entire sample size of all the combined LDN trials is still considerably small, and thus clinically valuable data and expertise are limited.
While not witnessed in investigations, some doctors have anecdotally reported tachycardia and anxiety as adverse effects of LDN. As anxiety is a recognized symptom of opioid withdrawal, possibly some individuals would encounter anxiety because of the inhibition of endogenous opioids. Further research will need to be conducted to conclude how prevalent this adverse event is and the best way to manage it.
For people without a severe hepatic condition, there does not appear to be any necessity of frequently monitoring hepatic function. Even in quite larger amounts, naltrexone does not greatly alter the activity of hepatic enzymes. No toxicity issues have been observed with chronic use.
No associated abuse potential
As an opioid blocker, naltrexone is given for the treatment of substance abuse. Low Dose Naltrexone doesn’t produce any euphoric or reinforcing influences, and we have witnessed no claims about misuse or abuse of LDN. Moreover, we have not observed the development of dependency and tolerance with the medicine. In our researches, the end of LDN therapy is usually accompanied by a slow return of signs and symptoms to baseline levels.
Reference post link: https://www.klusster.com/portfolios/donato-james/contents/116713?code=9591dda9-606c-4a53-ac95-89732e557379